منابع مشابه
Glucose variability and complications.
In this issue of the Diabetes Care, Kilpatrick et al. (1) report their analysis of the large Diabetes Control and Complications Trial (DCCT) database on the relationship between glucose variability and relative risk of developing microangiopathic complications in type 1 diabetes. They find that glucose variability (intraday blood glucose excursions) does not play a role and conclude that only e...
متن کاملClinical Implications of Glucose Variability: Chronic Complications of Diabetes
Glucose variability has been identified as a potential risk factor for diabetic complications; oxidative stress is widely regarded as the mechanism by which glycemic variability induces diabetic complications. However, there remains no generally accepted gold standard for assessing glucose variability. Representative indices for measuring intraday variability include calculation of the standard...
متن کاملGlucose Variability
The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenome...
متن کاملBiologic variability in plasma glucose, hemoglobin A1c, and advanced glycation end products associated with diabetes complications.
Plasma glucose plays a key role in the complications of diabetes mellitus. Hemoglobin A1c (HbA1c) and circulating concentrations of advanced glycation end products (AGEs) are central to diabetes clinical care and pathophysiology. However, there is evidence for variation between individuals in the relationship of plasma glucose to both these measures and to specific complications. The glycation ...
متن کاملLong-term study of the association of adipokines and glucose variability with diabetic complications
BACKGROUND/AIMS Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications. METHODS A tot...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2006
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc06-0716